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AT-NCIGT - The National Center for Advanced Technologies for Image Guided Therapy

Ferenc Jolesz First Monday Research Seminar Series

The Department of Radiology holds a monthly Ferenc Jolesz Seminar Series presented by Harvard Medical School investigators, as well as speakers from other institutions, on a wide range of topics related to image-guided therapy.
These seminars honor the late FERENC JOLESZ, MD who founded the multidisciplinary image-guided therapy program at Brigham and Women’s Hospital and is widely known as a founding father of the field of image-guided therapy.

UPCOMING SEMINARS

DATE: Monday, May 5th, 2025 | TIME: 12:15pm-1:15pm | LOCATION: This seminar will be held in the ANESTHESIA LECTURE HALL and via Zoom.

Located at 45 Francis Street entrance on the L1 level. Enter through the sliding doors at the 45 Francis Street entrance, go straight through the lobby. You will be on the 2nd floor. Take a left onto the 2nd floor hallway called “the Pike”. Continue straight until you see the Mary Horrigan Connors elevators on your right. Take these elevators to level L1. When you exit the elevators, look directly to your left. There will be a set of double doors with a sign for the Anesthesia Department. Enter through these double doors and continue straight until you reach a wall. Make a left and the room will be straight ahead.

Eva Gombos, MD: Intraoperative Supine Breast MRI in the Advanced Multimodality Image Guided Operating (AMIGO) suite

Gombos Eva

Eva Gombos, MD

Staff Radiologist
Department of Radiology
Director of Breast Imaging Research
Brigham and Women’s Hospital
Assistant Professor of Radiology
Harvard Medical School

About 15–30% of patients undergoing breast-conserving surgery (BCS) have positive margins, requiring re-excision to achieve clear margins. While pre-operative breast MRI is highly sensitive in assessing cancer extent, its effectiveness in reducing positive margins is not proven. One possible reason is the difference in breast shape and relative tumor location between the prone diagnostic MRI position and the supine surgical position.
In Phase 1, we developed an intraoperative supine MRI (isMRI) protocol in the AMIGO suite at Brigham and Women’s Hospital and demonstrated its feasibility during breast-conserving surgery (BCS). In a 15-patient study, isMRI was safe, sterile, and high-quality, revealing significant tumor deformation and position change between prone and supine positions. No residual tumors were detected post-surgery.
In Phase 2, a 43-patient study showed that isMRI had 80% accuracy and 93% specificity in detecting residual tumors at margins, reducing re-excision rates from 18% to 13%.
These results support isMRI’s potential to assess tumor location and deformation and guide real-time surgical decisions, improving outcomes and reducing repeat surgeries.

Dr. Eva Gombos is a board-certified Diagnostic Radiologist at the Brigham and Women’s Hospital (Mass General Brigham) and the Dana Farber Cancer Institute; and Assistant Professor of Radiology, Harvard Medical School.
Born in Hungary, she earned her MD from Semmelweis University in Budapest. She completed her residency in Diagnostic Radiology at the Kaplan Medical Center in Israel (1995), where she also subspecialized in Breast Imaging and served as Acting Section Head of Breast Imaging (1997-1998). She completed a Breast Imaging fellowship (1999-2000) and a residency/fellowship in Surgical Pathology (2000-2004) at the Mount Sinai Medical Center in Miami, FL. In 2004, she joined the Brigham and Women’s Hospital’s Breast Imaging Section, where she has been the Director of Breast Imaging Research since 2007.
She received an AUR GE Radiology Research Academic Fellowship (2008-2010) to study breast MRI, its diagnostic use and interrelation with other diagnostic specialties, particularly anatomic and molecular pathology. Her research interests focus on breast cancer imaging, particularly breast MRI, response assessment and radiology-pathology correlation.

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