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AT-NCIGT - The National Center for Advanced Technologies for Image Guided Therapy

Jeffrey Duryea, PhD: The MRI Osteoarthritis Software Score (MOSS): A Quantitative Method to Assess Knee Osteoarthritis


Jeffrey Duryea, PhD
Associate Professor, Harvard Medical School
Research Faculty Member, Department of Radiology, Brigham and Women’s Hospital


Radiological imaging is a proven technology for assessing structural changes produced by knee osteoarthritis (KOA). Conventional radiography is limited since it cannot be used to visualize the soft tissue structures, while magnetic resonance imaging (MRI) is an excellent modality for appreciating the full spectrum of features that can be indicators of the status and progression of KOA.

For research studies, KOA can be assessed using semi-quantitative scoring systems or using fully quantitative software methods to measure change. The latter has several advantages since the assessments are objective, can be performed quickly, and provide a true measure of the morphometry of the anatomical structures. We have developed the MRI Osteoarthritis Software Score (MOSS), a set of image analysis tools to measure KOA-related structures on MRI scans. Over the past decade we have made substantial progress in improving the efficiency of the methods such that a full assessment can be made in approximately 60 minutes per knee on average.

In this presentation, I will describe the different elements of MOSS and report the findings of several published and unpublished validation studies. I will report the preliminary results of a large study where we ultimately plan to assess many thousands of MRI data sets. I will also discuss future plans including the application of deep learning (DL) algorithms to further improve efficiency, and the integration of MOSS with accelerated MRI techniques.

Related Article: Quantitative measurement of medial femoral knee cartilage volume e analysis of the OA Biomarkers Consortium FNIH Study Cohort

Short Bio

Jeffrey is an Associate Professor of Radiology at Harvard Medical School, Brigham and Women’s Hospital. He received a PhD in physics from the University of Minnesota in 1991, completed a postdoctoral fellowship at the University of Michigan in 1993, and a post-graduate research appointment at the University of California, Davis Medical Center in 1994. From 1994 to 1996 he held a research scientist position at the Lunar Corporation before his appointment to the faculty of the University of California, San Francisco. In 2002 he joined the faculty at Harvard Medical School in the Radiology Department at Brigham and Women’s Hospital. He has spent the last 18 years of his career developing quantitative imaging-based methods to quantify the progression of arthritis and other musculoskeletal diseases. Jeffrey is the author of over 95 peer-reviewed publications and has been the principal investigator of six successful extramural peer-reviewed grants.

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