TRD 1 – IMAGING CANCER HETEROGENEITY

Integrating mass spectrometry imaging (MSI) of tissue metabolism, MRI, and histopathology for the assessment of brain tumor heterogeneity.

New diffusion imaging sequences to characterize cell architecture traits in prostate cancer.

New MRI pulse sequence for blood oxygenation mapping that accelerates acquisition speed more than ten-fold, without sacrificing volume coverage.

Chen Y, Zekelman LR, Zhang C, Xue T, Song Y, Makris N, Rathi Y, Golby AJ, Cai W, Zhang F, O’Donnell LJ. TractGeoNet: A Geometric Deep Learning Framework for Pointwise Analysis of Tract Microstructure to Predict Language Assessment Performance. Med Image Anal. 2024 May;94:103120. PMID: 38458095; PMCID: PMC11016451.

Juvekar P, Dorent R, Kögl F, Torio E, Barr C, Rigolo L, Galvin C, Jowkar N, Kazi A, Haouchine N, Cheema H, Navab N, Pieper S, Wells WM, Bi WL, Golby A, Frisken S, Kapur T. ReMIND: The Brain Resection Multimodal Imaging Database. medRxiv [Preprint]. 2024 Apr 8:2023.09.14.23295596. PMID: 37745329. PMC10516086.

Hwang GH, Pazyra-Murphy MF, Seo HS, Dhe-Paganon S, Stopka SA, DiPiazza M, Sutter N, Gero TW, Volkert A, Ombelets L, Dittemore G, Rees MG, Ronan MM, Roth JA, Agar NYR, Scott DA, Segal RA. A Benzarone Derivative Inhibits EYA to Suppress Tumor Growth in SHH Medulloblastoma. Cancer Res. 2024 15;84(6):872-886. PMID: 38486486; PMCID: PMC10948029.

Zhu A, Tarasek M, Hua Y, Fiveland E, Maier SE, Mazaheri Y, Fung M, Westin CF, Yeo DTB, Szczepankiewicz F, Tempany C, Akin O, Foo TKF. Human Prostate MRI at Ultrahigh-performance Gradient: A Feasibility Study. Magn Reson Med. 2024 Feb;91(2):640-8. PMID: 37753628. PMC10841413.

Langbein BJ, Berk B, Bay C, Tuncali K, Martin N, Schostak M, Fennessy F, Tempany C, Kibel AS, Cole AP. A Phase II Prospective Blinded Trial of Magnetic Resonance Imaging and In-Bore Biopsy in Active Surveillance for Prostate Cancer. Urology. 2024 Jan 11:S0090-4295(23)01122-6. PMID: 38218388.

Miller A, York EM, Stopka SA, Martínez-François JR, Hossain MA, Baquer G, Regan MS, Agar NYR, Yellen G. Spatially Resolved Metabolomics and Isotope Tracing Reveal Dynamic Metabolic Responses of Dentate Granule Neurons With Acute Stimulation. Nat Metab. 2023 Oct;5(10):1820-35. PMID: 37798473. PMC10626993.

Fennessy FM, Maier SE. Quantitative Diffusion MRI in Prostate Cancer: Image Quality, What We Can Measure and How It Improves Clinical Assessment. Eur J Radiol. 2023 Oct;167:111066. PMID: 37651828. PMC10623580.

Safdar S, Zwick BF, Yu Y, Bourantas GC, Joldes GR, Warfield SK, Hyde DE, Frisken S, Kapur T, Kikinis R, Golby A, Nabavi A, Wittek A, Miller K. SlicerCBM: Automatic Framework for Biomechanical Analysis of the Brain. Int J Comput Assist Radiol Surg. 2023 Oct;18(10):1925-40. PMID: 37004646. PMC10497672.

Gottumukkala RV, Lee LK, Tu W, Tempany CM, Fennessy FM. Local Staging of Prostate Cancer at MRI: What the Urologist and Radiation Oncologist Want to Know. Radiographics. 2023 Sep;43(9):e220100. PMID: 37561642. PMC10506065.

Moreira P, Tuncali K, Tempany C, Tokuda J. AI-Based Isotherm Prediction for Focal Cryoablation of Prostate Cancer. Acad Radiol. 2023 Sep;30 Suppl 1:S14-S20. PMID: 37236896. PMC10524864.

Stopka SA, Ruiz D, Baquer G, Bodineau C, Hossain MA, Pellens VT, Regan MS, Pourquié O, Haigis MC, Bi WL, Coy SM, Santagata S, Agar NYR, Basu SS. Chemical QuantArray: A Quantitative Tool for Mass Spectrometry Imaging. Anal Chem. 2023 Aug 1;95(30):11243-11253. PMID: 37469028. PMC10445330.

Fütterer JJ, Tempany C. Prostate MRI and Image Quality: The Radiologist’s Perspective. Eur J Radiol. 2023 Aug;165:110930. PMID: 37364484. PMC10466385.

Miller A, York E, Stopka SA, Martinex-Francois J, Hossain MA, Baquer G, Regan M, Agar NYR, Yellen G. Spatially Resolved Metabolomics and Isotope Tracing Reveal Dynamic Metabolic Responses of Dentate Granule Neurons with Acute Stimulation. Res Sq. 2023 Jul 25;rs.3.rs-2276903. PMID: 37546759. PMC10402263.

Burk KS, Naik S, Lacson R, Tuncali K, Lee LK, Tempany C, Cole AP, Trinh QD, Kibel AS, Khorasani R. MRI-Targeted, Systematic, or Combined Biopsy for Detecting Clinically Significant Prostate Cancer. J Am Coll Radiol. 2023 Jul;20(7):687-695. PMID: 37315913. PMC10528090.

Conage-Pough JE, Stopka SA, Oh JH, Mladek AC, Burgenske DM, Regan MS, Baquer G, Decker PA, Carlson BL, Bakken KK, Zhang J, Liu L, Sun C, Mu Z, Zhong W, Tran NL, Elmquist WF, Agar NYR, Sarkaria JN, White FM. WSD-0922, a Novel Brain-Penetrant Inhibitor of Epidermal Growth Factor Receptor, Promotes Survival in Glioblastoma Mouse Models.
Neurooncol Adv. 2023 May 27;5(1):vdad066. PMID: 37324218. PMC10263119.

Koelker M, Labban M, Frego N, Meyer CP, Salomon G, Lipsitz SR, Withington J, Moore CM, Tempany CM, Tuncali K, George A, Kibel AS, Trinh QD, Cole AP. Contemporary Patterns of Local Ablative Therapies for Prostate Cancer at United States Cancer Centers: Results From a National Registry. World J Urol. 2023 May;41(5):1309-1315. PMID: 36930254; PMC10506077.

Camacho A, Salah F, Bay CP, Waring J, Umeton R, Hirsch MS, Cole AP, Kibel AS, Loda M, Tempany CM, Fennessy FM. PI-RADS 3 Score: A Retrospective Experience of Clinically Significant Prostate Cancer Detection. BJUI Compass. 2023 Apr 11;4(4):473-481. PMID: 37334024. PMC10268585.

Haque MIU, Mukherjee D, Stopka SA, Agar NYR, Hinkle J, Ovchinnikova OS. Deep Learning on Multimodal Chemical and Whole Slide Imaging Data for Predicting Prostate Cancer Directly from Tissue Images. J Am Soc Mass Spectrom. 2023 Feb 1;34(2):227-235. PMID: 36625762. PMC10479534.

Giganti F, Cole AP, Fennessy FM, Clinton T, Moreira PLDF, Bernardes MC, Westin CF, Krishnaswamy D, Fedorov a, Wollin DA, Langbein B, Frego N, Labban M, Badaoui JS, Chang SL, Briggs LG, Tokuda J, Ambrosi A, Kirkham A, Emberton M, Kasivisvanathan V, Moore CM, Allen C, Tempany CM. Promoting the Use of the PI- QUAL Score for Prostate MRI Quality: Results From the ESOR Nicholas Gourtsoyiannis Teaching Fellowship. Eur Radiol. 2023 Jan;33(1):461-471. PMID: 35771247. PMC9244244.

Juvekar P, Torio E, Bi WL, Bastos DCA, Golby AJ, Frisken SF. Mapping Resection Progress by Tool-Tip Tracking During Brain Tumor Surgery for Real-Time Estimation of Residual Tumor. Cancers (Basel). 2023 Jan 29;15(3):825. PMID: 36765783. PMC9913508.

Kögl FV, Léger É, Haouchine N, Torio E, Juvekar P, Navab N, Kapur T, Pieper S, Golby A, Frisken S.
A Tool-Free Neuronavigation Method Based on Single-View Hand Tracking. Comput Methods Biomech Biomed Eng Imaging Vis. 2023;11(4):1307-15. PMID: 37457380. PMC10348700.