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AT-NCIGT - The National Center for Advanced Technologies for Image Guided Therapy

In the AMIGO suite, we have developed a new surgical approach for treatment of small lung nodules, lesions that are not obviously malignant, but could harbor early lung cancer. If surgical resection is warranted, these lesions are often difficult to palpate, necessitating a large resection of lung tissue to ensure that the lesion is completely removed. Our protocol utilizes the intraoperative fluoroscopy and C-arm CT capability of the AMIGO suite to place image-guided fiducials around these small lung lesions and improve the precision in localizing the lesions. The protocol has enabled our precise targeting of lung tumors and minimizing the extent to which normal lung tissue is resected while achieving adequate surgical margins. With the recently developed guidelines for screening smokers with low-dose CT, many more small lung nodules are expected to be detected. The successful development of our surgical approach using the AMIGO suite could prove highly beneficial to patients with these lesions.

Image-guided targeting of lesions for surgical resection is not a new concept. However, many current techniques are without the benefit of fiducial placement with intraoperative fluoro-CT, relying, instead, on preoperative image guidance or on intraoperative ultrasound guidance. These techniques are associated with the risk of complications and the limitations of image resolution. Our surgical approach in AMIGO utilizes C-arm CT image guidance in a controlled operating room setting. It is designed to maximize patient safety while using C-arm CT imaging to target small lung lesions so that pathologic lung tissue may be completely excised while preserving as much normal lung tissue as possible.

Lung cancer remains the deadliest malignancy. The National Lung Cancer Screening Trial found that screening smokers who fit the criteria using low-dose CT has a significant impact on reducing mortality. The screening detects with precision many small lung lesions and our new surgical approach has demonstrated safe and effective preliminary results for excising these lesions with precision. We plan to continue evaluating the long-term outcomes so that our surgical approach can be translated for use in other clinical settings. Hybrid operating rooms like the AMIGO suite are becoming more prevalent. In clinical setting without this technology, our surgical approach may be adapted for use with preoperative CT image guidance to place the fiducials marking the small lung lesion.

This case study below illustrates the iVATS workflow in AMIGO. A 20-year-old male was diagnosed with a small lesion in the right lower lobe of the lung. Preoperative PET-CT showed a 9 x 7 mm lung nodule that was also visible on PET imaging. Localizing such a small lesion by finger palpation intraoperatively is almost impossible, and so an entire lobe of a 20-year-old patient would have had to be removed. The patient underwent an iVATS procedure in AMIGO. Using the techniques we developed, we were able to accurately localize the lesion intraoperatively under C-arm CT guidance using two imaging fiducials called T-bars. Thereafter, using these two fiducials as surrogate markers for the tumor, the surgeon identified the lesion and performed a wedge resection surgery. Pathology results confirmed that the lesion was a carcinoid and the margins were negative.

Thoracoscopic Surgery (iVats) Workflow in AMIGO

CT image showing the tumor

3D model showing the skeleton (white), lung (brown), trachea (purple) and tumor (green)

Magnified view of the tumor

C-Arm CT of the patient in surgical position (left lateral decubitus)

Setup in AMIGO: surgeon and radiologist working together

Setup in AMIGO
C-Arm retracted to allow for surgery to continue

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