The 12th National Image Guided Therapy Workshop was held on May 19, 2022, in virtual format. The workshop drew 289 registrations, including 29 NIH personnel and 48 industry representatives. The workshop started with four plenary lecturers covering state-of-art Image Guided Therapy research: Dr. Kim Butts-Pauly of Stanford University introduced her recent progress on Focused Ultrasound Therapy, and Dr. Oliver Jonas of Harvard Medical School on Drug Response measurements by intra-tumor device, Dr. Mathias Unberath on In Silico Experiment, and Dr. Ken Goldberg of UC Berkley on Artificial Intelligence robotic surgery. The plenary talks were followed by 35 oral presentations by Principal Investigators of active NIH grants on Image Guided Therapy research and 30 short presentations by fellows and post-docs to discuss their research progress with experts. The research presentation topics included Medical Robotics, Surgical technologies, Imaging and Sensing Technologies, and MRI-guided Focused Ultrasound therapies. The website for the workshop consists of the participants’ list and titles and authors of the talks. The link to the grants’ NIH Reporter page is provided for the talks covering the active NIH funding.