Recent Publications
- Data-driven adaptive needle insertion assist for transperineal prostate interventions April 20, 2023Objective.Clinical outcomes of transperineal prostate interventions, such as biopsy, thermal ablations, and brachytherapy, depend on accurate needle placement for effectiveness. However, the accurate placement of a long needle, typically 150-200 mm in length, is challenging due to needle deviation induced by needle-tissue interaction. While several approaches for needle trajectory correction have been studied, many of […]Mariana C Bernardes
- SlicerCBM: automatic framework for biomechanical analysis of the brain April 2, 2023CONCLUSION: Our framework provides a broader application of existing solution methods not only in research but also in clinics. We successfully demonstrated the application of our framework by predicting intra-operative deformations in nine patients undergoing neurosurgical procedures.Saima Safdar
- Mapping Resection Progress by Tool-Tip Tracking during Brain Tumor Surgery for Real-Time Estimation of Residual Tumor February 11, 2023Surgical resection continues to be the primary initial therapeutic strategy in the treatment of patients with brain tumors. Computerized cranial neuronavigation based on preoperative imaging offers precision guidance during craniotomy and early tumor resection but progressively loses validity with brain shift. Intraoperative MRI (iMRI) and intraoperative ultrasound (iUS) can update the imaging used for guidance […]Parikshit Juvekar
- Global cancer surgery in low-resource settings: A strengths, weaknesses, opportunities, and threats analysis January 4, 2023Global cancer surgery is an essential and complex component of oncologic care. This study aims to describe global cancer surgery literature since the 2015 Lancet Commission on Global Surgery and Cancer Surgery and perform a strengths, weaknesses, opportunities, and threats (SWOT) analysis. A systematic search was performed in PubMed of global cancer surgery articles. Themes […]Samantha J Sadler
- SurfaceNets for Multi-Label Segmentations with Preservation of Sharp Boundaries November 3, 2022We extend 3D SurfaceNets to generate surfaces of segmented 3D medical images composed of multiple materials represented as indexed labels. Our extension generates smooth, high-quality triangle meshes suitable for rendering and tetrahedralization, preserves topology and sharp boundaries between materials, guarantees a user-specified accuracy, and is fast enough that users can interactively explore the trade-off between […]Sarah F Frisken
- BAF Complex Maintains Glioma Stem Cells in Pediatric H3K27M Glioma October 28, 2022Diffuse midline gliomas are uniformly fatal pediatric central nervous system cancers that are refractory to standard-of-care therapeutic modalities. The primary genetic drivers are a set of recurrent amino acid substitutions in genes encoding histone H3 (H3K27M), which are currently undruggable. These H3K27M oncohistones perturb normal chromatin architecture, resulting in an aberrant epigenetic landscape. To interrogate […]Eshini Panditharatna
- Quantitative Analysis of Liver Disease Using MRI-Based Radiomic Features of the Liver and Spleen October 26, 2022CONCLUSIONS: MR-based liver and spleen radiomic features had high accuracy in identifying cirrhosis, after stratification by clinical compensation/decompensation and MELD. Shape and texture features performed better than size features. These findings will inform radiomic-based applications for cirrhosis diagnosis and severity.Jordan Sack
- Multimodal Representation Learning via Maximization of Local Mutual Information October 25, 2022We propose and demonstrate a representation learning approach by maximizing the mutual information between local features of images and text. The goal of this approach is to learn useful image representations by taking advantage of the rich information contained in the free text that describes the findings in the image. Our method trains image and […]Ruizhi Liao
- Radiologists' Contribution to Variation in Detecting Clinically Significant Prostate Cancer in Men With Prostate MRI October 16, 2022OBJECTIVE: Assess radiologists' contribution to variation in clinically significant prostate cancer (csPCa) detection in patients with elevated prostate-specific antigen (PSA) and multiparametric MRI (mpMRI).Sachin Naik
- Chronic convection-enhanced delivery of topotecan for patients with recurrent glioblastoma: a first-in-patient, single-centre, single-arm, phase 1b trial October 15, 2022BACKGROUND: Topotecan is cytotoxic to glioma cells but is clinically ineffective because of drug delivery limitations. Systemic delivery is limited by toxicity and insufficient brain penetrance, and, to date, convection-enhanced delivery (CED) has been restricted to a single treatment of restricted duration. To address this problem, we engineered a subcutaneously implanted catheter-pump system capable of […]Eleonora F Spinazzi
- Oncometabolite d-2HG alters T cell metabolism to impair CD8<sup>+</sup> T cell function September 29, 2022Gain-of-function mutations in isocitrate dehydrogenase (IDH) in human cancers result in the production of d-2-hydroxyglutarate (d-2HG), an oncometabolite that promotes tumorigenesis through epigenetic alterations. The cancer cell-intrinsic effects of d-2HG are well understood, but its tumor cell-nonautonomous roles remain poorly explored. We compared the oncometabolite d-2HG with its enantiomer, l-2HG, and found that tumor-derived d-2HG […]Giulia Notarangelo
- Automatic segmentation of prostate and extracapsular structures in MRI to predict needle deflection in percutaneous prostate intervention September 24, 2022CONCLUSION: Our segmentation method using 3D U-Net provided an accurate anatomical understanding of the prostate and extracapsular structures. In addition, our method was suitable for segmenting functional and complication-related structures. Finally, 3D images of the prostate and extracapsular structures could simulate the needle pathway to predict needle deflections.Satoshi Kobayashi
- Spatially resolved characterization of tissue metabolic compartments in fasted and high-fat diet livers September 6, 2022Cells adapt their metabolism to physiological stimuli, and metabolic heterogeneity exists between cell types, within tissues, and subcellular compartments. The liver plays an essential role in maintaining whole-body metabolic homeostasis and is structurally defined by metabolic zones. These zones are well-understood on the transcriptomic level, but have not been comprehensively characterized on the metabolomic level. […]Sylwia A Stopka
- Highdicom: a Python Library for Standardized Encoding of Image Annotations and Machine Learning Model Outputs in Pathology and Radiology August 22, 2022Machine learning (ML) is revolutionizing image-based diagnostics in pathology and radiology. ML models have shown promising results in research settings, but the lack of interoperability between ML systems and enterprise medical imaging systems has been a major barrier for clinical integration and evaluation. The DICOM^(®) standard specifies information object definitions (IODs) and services for the […]Christopher P Bridge
- A druggable addiction to de novo pyrimidine biosynthesis in diffuse midline glioma August 19, 2022Diffuse midline glioma (DMG) is a uniformly fatal pediatric cancer driven by oncohistones that do not readily lend themselves to drug development. To identify druggable targets for DMG, we conducted a genome-wide CRISPR screen that reveals a DMG selective dependency on the de novo pathway for pyrimidine biosynthesis. This metabolic vulnerability reflects an elevated rate […]Sharmistha Pal
- De novo pyrimidine synthesis is a targetable vulnerability in IDH mutant glioma August 19, 2022Mutations affecting isocitrate dehydrogenase (IDH) enzymes are prevalent in glioma, leukemia, and other cancers. Although mutant IDH inhibitors are effective against leukemia, they seem to be less active in aggressive glioma, underscoring the need for alternative treatment strategies. Through a chemical synthetic lethality screen, we discovered that IDH1-mutant glioma cells are hypersensitive to drugs targeting […]Diana D Shi
- Single cell spatial analysis reveals the topology of immunomodulatory purinergic signaling in glioblastoma August 16, 2022How the glioma immune microenvironment fosters tumorigenesis remains incompletely defined. Here, we use single-cell RNA-sequencing and multiplexed tissue-imaging to characterize the composition, spatial organization, and clinical significance of extracellular purinergic signaling in glioma. We show that microglia are the predominant source of CD39, while tumor cells principally express CD73. In glioblastoma, CD73 is associated with […]Shannon Coy
- Superficial white matter microstructure affects processing speed in cerebral small vessel disease July 13, 2022White matter hyperintensities (WMH) are a typical feature of cerebral small vessel disease (CSVD), which contributes to about 50% of dementias worldwide. Microstructural alterations in deep white matter (DWM) have been widely examined in CSVD. However, little is known about abnormalities in superficial white matter (SWM) and their relevance for processing speed, the main cognitive […]Shuyue Wang
- Promoting the use of the PI-QUAL score for prostate MRI quality: results from the ESOR Nicholas Gourtsoyiannis teaching fellowship June 30, 2022CONCLUSIONS: A teaching course (dedicated lecture + hands-on workshop) on PI-QUAL significantly improved the application of this scoring system to assess the quality of prostate MRI examinations.Francesco Giganti
- Multicenter Repeatability and Reproducibility of MR Fingerprinting in Phantoms and in Prostatic Tissue June 17, 2022CONCLUSION: Prostate MRF measurements of T(1) and T(2) are repeatable and reproducible between MRI scanners at different centers on different continents for the above measurement ranges.Wei-Ching Lo
Safdar S, Zwick BF, Yu Y, Bourantas GC, Joldes GR, Warfield SK, Hyde DE, Frisken S, Kapur T, Kikinis R, Golby A, Nabavi A, Wittek A, Miller K. SlicerCBM: automatic framework for biomechanical analysis of the brain. Int J Comput Assist Radiol Surg. 2023 Apr 1. PMID: 37004646.
Zheng J, Yang Q, Makris N, Huang K, Liang J, Ye C, Yu X, Tian M, Ma T, Mou T, Guo W, Kikinis R, Gao Y. Three-Dimensional Digital Reconstruction of the Cerebellar Cortex: Lobule Thickness, Surface Area Measurements, and Layer Architecture. Cerebellum. 2023 Apr;22(2):249-260. PMID: 35286708; PMC9470778.
Sadler SJ, Torio EF, Golby AJ. Global cancer surgery in low-resource settings: A strengths, weaknesses, opportunities, and threats analysis. Cancer. 2023 Mar 1;129(5):671-684. PMID: 36597652; PMC10069626.
Kobayashi S, King F, Hata N. Automatic segmentation of prostate and extracapsular structures in MRI to predict needle deflection in percutaneous prostate intervention. Int J Comput Assist Radiol Surg. 2023 Mar;18(3):449-460. PMID: 36152168; PMC9974805.
Juvekar P, Torio E, Bi WL, Bastos DCA, Golby AJ, Frisken SF. Mapping Resection Progress by Tool-Tip Tracking during Brain Tumor Surgery for Real-Time Estimation of Residual Tumor. Cancers (Basel). 2023 Jan 29;15(3):825. PMID: 36765783; PMC9913508.
Giganti F, Cole AP, Fennessy FM, Clinton T, Moreira PLDF, Bernardes MC, Westin CF, Krishnaswamy D, Fedorov A, Wollin DA, Langbein B, Frego N, Labban M, Badaoui JS, Chang SL, Briggs LG, Tokuda J, Ambrosi A, Kirkham A, Emberton M, Kasivisvanathan V, Moore CM, Allen C, Tempany CM. Promoting the use of the PI-QUAL score for prostate MRI quality: results from the ESOR Nicholas Gourtsoyiannis teaching fellowship. Eur Radiol. 2023 Jan;33(1):461-471. PMID: 35771247; PMC9244244.
Panditharatna E, Marques JG, Wang T, Trissal MC, Liu I, Jiang L, Beck a, Groves a, Dharia NV, Li D, Hoffman SE, Kugener G, Shaw ML, Mire HM, Hack OA, Dempster JM, Lareau C, Dai L, Sigua LH, Quezada MA, Stanton AJ, Wyatt M, Kalani Z, Goodale a, Vazquez F, Piccioni F, Doench JG, Root DE, Anastas JN, Jones KL, Conway as, Stopka S, Regan MS, Liang Y, Seo HS, Song K, Bashyal P, Jerome WP, Mathewson ND, Dhe-Paganon S, Suvà ML, Carcaboso AM, Lavarino C, Mora J, Nguyen QD, Ligon KL, Shi Y, Agnihotri S, Agar NYR, Stegmaier K, Stiles CD, Monje M, Golub TR, Qi J, Filbin MG. BAF Complex Maintains Glioma Stem Cells in Pediatric H3K27M Glioma. Cancer Discov. 2022 Dec 2;12(12):2880-2905. PMID: 36305736; PMC9716260.
Naik S, Burk KS, Budiawan E, Lacson R, Lee LK, Fennessy FM, Tempany C, Cole AP, Trinh QD, Kibel as, Khorasani R. Radiologists’ Contribution to Variation in Detecting Clinically Significant Prostate Cancer in Men With Prostate MRI. J Am Coll Radiol. 2022 Dec;19(12):1312-1321. PMID: 36244674.
Bridge CP, Gorman C, Pieper S, Doyle SW, Lennerz JK, Kalpathy-Cramer J, Clunie DA, Fedorov AY, Herrmann MD. Highdicom: A Python Library for Standardized Encoding of Image Annotations and Machine Learning Model Outputs in Pathology and Radiology. J Digit Imaging. 2022 Dec;35(6):1719-1737. PMID: 35995898; PMC9712874.
Wang S, Zhang F, Huang P, Hong H, Jiaerken Y, Yu X, Zhang R, Zeng Q, Zhang Y, Kikinis R, Rathi Y, Makris N, Lou M, Pasternak O, Zhang M, O’Donnell LJ. Superficial White Matter Microstructure Affects Processing Speed in Cerebral Small Vessel Disease. Hum Brain Mapp. 2022 Dec 1;43(17):5310-5325. PMID: 35822593; PMC9812245.
Spinazzi EF, Argenziano MG, Upadhyayula PS, Banu MA, Neira JA, Higgins DMO, Wu PB, Pereira B, Mahajan a, Humala N, Al-Dalahmah O, Zhao W, Save AV, Gill BJA, Boyett DM, Marie T, Furnari JL, Sudhakar TD, Stopka SA, Regan MS, Catania v, Good L, Zacharoulis S, Behl M, Petridis P, Jambawalikar S, Mintz a, Lignelli a, Agar NYR, Sims PA, Welch MR, Lassman AB, Iwamoto FM, D’Amico RS, Grinband J, Canoll P, Bruce JN. Chronic Convection-Enhanced Delivery of Topotecan for Patients With Recurrent Glioblastoma: A First-in-Patient, Single-Centre, Single- Arm, Phase 1b Trial. Lancet Oncol. 2022 Nov;23(11):1409-1418. PMID: 36243020; PMC9641975.
Sack J, Nitsch J, Meine H, Kikinis R, Halle M, Rutherford a. Quantitative Analysis of Liver Disease Using MRI-Based Radiomic Features of the Liver and Spleen. J Imaging. 2022 Oct 9;8(10):277. PMID: 36286371; PMC9605113.
Lo WC, Bittencourt LK, Panda a, Jiang Y, Tokuda J, Seethamraju R, Tempany- Afdhal C, Obmann v, Wright K, Griswold M, Seiberlich N, Gulani v. Multicenter Repeatability and Reproducibility of MR Fingerprinting in Phantoms and in Prostatic Tissue. Magn Reson Med. 2022 Oct;88(4):1818-1827. PMID: 35713379; PMC9469467.
Notarangelo G, Spinelli JB, Perez EM, Baker GJ, Kurmi K, Elia I, Stopka SA, Baquer G, Lin JR, Golby AJ, Joshi S, Baron HF, Drijvers JM, Georgiev P, Ringel AE, Zaganjor E, McBrayer SK, Sorger PK, Sharpe AH, Wucherpfennig KW, Santagata S, Agar NYR, Suvà ML, Haigis MC. Oncometabolite D-2HG Alters T Cell Metabolism to Impair CD8<Sup>+</Sup> T Cell Function. Science. 2022 Sep 30;377(6614):1519-1529. PMID: 36173860; PMC9629749.
Shi DD, Savani MR, Levitt MM, Wang AC, Endress JE, Bird CE, Buehler J, Stopka SA, Regan MS, Lin YF, Puliyappadamba VT, Gao W, Khanal J, Evans L, Lee JH, Guo L, Xiao Y, Xu M, Huang B, Jennings RB, Bonal DM, Martin-Sandoval MS, Dang T, Gattie LC, Cameron AB, Lee S, Asara JM, Kornblum HI, Mak TW, Looper RE, Nguyen QD, Signoretti S, Gradl S, Sutter a, Jeffers M, Janzer a, Lehrman MA, Zacharias LG, Mathews TP, Losman JA, Richardson TE, Cahill DP, DeBerardinis RJ, Ligon KL, Xu L, Ly P, Agar NYR, Abdullah KG, Harris IS, Kaelin WG Jr, McBrayer SK. De Novo Pyrimidine Synthesis Is a Targetable Vulnerability in IDH Mutant Glioma. Cancer Cell. 2022 Sep 12;40(9):939-956.e16. PMID: 35985343; PMC9515386.
Pal S, Kaplan JP, Nguyen H, Stopka SA, Savani MR, Regan MS, Nguyen QD, Jones KL, Moreau LA, Peng J, Dipiazza MG, Perciaccante AJ, Zhu X, Hunsel BR, Liu KX, Alexandrescu S, Drissi R, Filbin MG, McBrayer SK, Agar NYR, Chowdhury D, Haas- Kogan DA. A Druggable Addiction to De Novo Pyrimidine Biosynthesis in Diffuse Midline Glioma. Cancer Cell. 2022 Sep 12;40(9):957-972.e10. PMID: 35985342; PMC9575661.
Stopka SA, Van Der Reest J, Abdelmoula WM, Ruiz DF, Joshi S, Ringel AE, Haigis MC, Agar NYR. Spatially Resolved Characterization of Tissue Metabolic Compartments in Fasted and High-Fat Diet Livers. PLoS One. 2022 Sep 6;17(9):e0261803. PMID: 36067168; PMC9447892.
Coy S, Wang S, Stopka SA, Lin JR, Yapp C, Ritch CC, Salhi L, Baker GJ, Rashid R, Baquer G, Regan M, Khadka P, Cole KA, Hwang J, Wen PY, Bandopadhayay P, Santi M, De Raedt T, Ligon KL, Agar NYR, Sorger PK, Touat M, Santagata S. Single Cell Spatial Analysis Reveals the Topology of Immunomodulatory Purinergic Signaling in Glioblastoma. Nat Commun. 2022 Aug 16;13(1):4814. PMID: 35973991; PMC9381513.
Ehdaie B, Tempany CM, Holland F, Sjoberg DD, Kibel as, Trinh QD, Durack JC, Akin O, Vickers AJ, Scardino PT, Sperling D, Wong JYC, Yuh B, Woodrum DA, Mynderse LA, Raman SS, Pantuck AJ, Schiffman MH, McClure TD, Sonn GA, Ghanouni P. MRI-Guided Focused Ultrasound Focal Therapy for Patients With Intermediate- Risk Prostate Cancer: A Phase 2b, Multicentre Study. Lancet Oncol. 2022 Jul;23(7):910-918. PMID: 35714666; PMC9400094.
Sefcikova v, Sporrer JK, Juvekar P, Golby a, Samandouras G. Converting Sounds to Meaning With Ventral Semantic Language Networks: Integration of Interdisciplinary Data on Brain Connectivity, Direct Electrical Stimulation and Clinical Disconnection Syndromes. Brain Struct Funct. 2022 Jun;227(5):1545-1564. PMID: 35267079; PMC9098557.
Zhang F, Wells WM, O’Donnell LJ. Deep Diffusion MRI Registration (DDMReg): A Deep Learning Method for Diffusion MRI Registration. IEEE Trans Med Imaging. 2022 Jun;41(6):1454-1467. PMID: 34968177; PMC9273049.
McGarry SD, Brehler M, Bukowy JD, Lowman AK, Bobholz SA, Duenweg SR, Banerjee a, Hurrell SL, Malyarenko D, Chenevert TL, Cao Y, Li Y, You D, Fedorov a, Bell LC, Quarles CC, Prah MA, Schmainda KM, Taouli B, LoCastro E, Mazaheri Y, Shukla-Dave a, Yankeelov TE, Hormuth DA 2nd, Madhuranthakam AJ, Hulsey K, Li K, Huang W, Huang W, Muzi M, Jacobs MA, Solaiyappan M, Hectors S, Antic T, Paner GP, Palangmonthip W, Jacobsohn K, Hohenwalter M, Duvnjak P, Griffin M, See W, Nevalainen MT, Iczkowski KA, LaViolette PS. Multi-Site Concordance of Diffusion- Weighted Imaging Quantification for Assessing Prostate Cancer Aggressiveness. J Magn Reson Imaging. 2022 Jun;55(6):1745-1758. PMID: 34767682; PMC9095769.
Pujol S, Cabeen RP, Yelnik J, François C, Fernandez Vidal S, Karachi C, Bardinet E, Cosgrove GR, Kikinis R. Somatotopic Organization of Hyperdirect Pathway Projections From the Primary Motor Cortex in the Human Brain. Front Neurol. 2022 Apr 25;13:791092. PMID: 35547388; PMC9081715.
Abdelmoula WM, Stopka SA, Randall EC, Regan M, Agar JN, Sarkaria JN, Wells WM, Kapur T, Agar NYR. massNet: Integrated Processing and Classification of Spatially Resolved Mass Spectrometry Data Using Deep Learning for Rapid Tumor Delineation. Bioinformatics. 2022 Mar 28;38(7):2015-2021. PMID: 35040929; PMC8963284.
Sebastian C, Ferrer C, Serra M, Choi JE, Ducano N, Mira a, Shah MS, Stopka SA, Perciaccante AJ, Isella C, Moya-Rull D, Vara-Messler M, Giordano S, Maldi E, Desai N, Capen DE, Medico E, Cetinbas M, Sadreyev RI, Brown D, Rivera MN, Sapino a, Breault DT, Agar NYR, Mostoslavsky R. A Non-Dividing Cell Population With High Pyruvate Dehydrogenase Kinase Activity Regulates Metabolic Heterogeneity and Tumorigenesis in the Intestine. Nat Commun. 2022 Mar 21;13(1):1503. PMID: 35314684; PMC8938512.
Cole AP, Langbein BJ, Giganti F, Fennessy FM, Tempany CM, Emberton M. Is Perfect the Enemy of Good? Weighing the Evidence for Biparametric MRI in Prostate Cancer. Br J Radiol. 2022 Mar 1;95(1131):20210840. PMID: 34826223; PMC8978228.
Maier-Hein L, Eisenmann M, Sarikaya D, März K, Collins T, Malpani a, Fallert J, Feussner H, Giannarou S, Mascagni P, Nakawala H, Park a, Pugh C, Stoyanov D, Vedula SS, Cleary K, Fichtinger G, Forestier G, Gibaud B, Grantcharov T, Hashizume M, Heckmann-Nötzel D, Kenngott HG, Kikinis R, Mündermann L, Navab N, Onogur S, Roß T, Sznitman R, Taylor RH, Tizabi MD, Wagner M, Hager GD, Neumuth T, Padoy N, Collins J, Gockel I, Goedeke J, Hashimoto DA, Joyeux L, Lam K, Leff DR, Madani a, Marcus HJ, Meireles O, Seitel a, Teber D, Ückert F, Müller-Stich BP, Jannin P, Speidel S. Surgical Data Science – From Concepts Toward Clinical Translation. Med Image Anal. 2022 Feb;76:102306. PMID: 34879287; PMC9135051.
Zekelman LR, Zhang F, Makris N, He J, Chen Y, Xue T, Liera D, Drane DL, Rathi Y, Golby AJ, O’Donnell LJ. White Matter Association Tracts Underlying Language and Theory of Mind: An Investigation of 809 Brains From the Human Connectome Project. Neuroimage. 2022 Feb 1;246:118739. PMID: 34856375; PMC8862285.
Robles DJ, Dharani a, Rostowsky KA, Chaudhari NN, Ngo v, Zhang F, O’Donnell LJ, Green L, Sheikh-Bahaei N, Chui HC, Irimia a. Older Age, Male Sex, and Cerebral Microbleeds Predict White Matter Loss After Traumatic Brain Injury. Geroscience. 2022 Feb;44(1):83-102. PMID: 34704219; PMC8811069.
Yu Y, Safdar S, Bourantas G, Zwick B, Joldes G, Kapur T, Frisken S, Kikinis R, Nabavi a, Golby a, Wittek a, Miller K. Automatic Framework for Patient- Specific Modelling of Tumour Resection-Induced Brain Shift. Comput Biol Med. 2022 Jan 30;143:105271. PMID: 35123136; PMC9389918.
Madore B, Belsley G, Cheng CC, Preiswerk F, Kijewski MF, Wu PH, Martell LB, Pluim JPW, Di Carli M, Moore SC. Ultrasound-Based Sensors for Respiratory Motion Assessment in Multimodality PET Imaging. Phys Med Biol. 2022 Jan 19;67(2):10.1088/1361-6560/ac4213. PMID: 34891142; PMC9482332.
Lopez BGC, Kohale in, Du Z, Korsunsky I, Abdelmoula WM, Dai Y, Stopka SA, Gaglia G, Randall EC, Regan MS, Basu SS, Clark AR, Marin BM, Mladek AC, Burgenske DM, Agar JN, Supko JG, Grossman SA, Nabors LB, Raychaudhuri S, Ligon KL, Wen PY, Alexander B, Lee EQ, Santagata S, Sarkaria J, White FM, Agar NYR. Multimodal Platform for Assessing Drug Distribution and Response in Clinical Trials. Neuro Oncol. 2022 Jan 5;24(1):64-77. PMID: 34383057; PMC8730776.
Frisken SF. SurfaceNets for Multi-Label Segmentations With Preservation of Sharp Boundaries. J Comput Graph Tech. 2022 Jan-Mar;11(1):34-54. PMID: 36325473; PMC9623606.
Yu Y, Bourantas G, Zwick B, Joldes G, Kapur T, Frisken S, Kikinis R, Nabavi a, Golby a, Wittek a, Miller K. Computer Simulation of Tumour Resection-Induced Brain Deformation by a Meshless Approach. Int J Numer Method Biomed Eng. 2022 Jan;38(1):e3539. PMID: 34647427; PMC8881972.
Dominas C, Bhagavatula S, Stover E, Deans K, Larocca C, Colson Y, Peruzzi P, Kibel a, Hata N, Tsai L, Hung Y, Packard R, Jonas O. The Translational and Regulatory Development of an Implantable Microdevice for Multiple Drug Sensitivity Measurements in Cancer Patients. IEEE Trans Biomed Eng. 2022 Jan;69(1):412-421. PMID: 34242160; PMC8702455.
Zhou H, Jayender J. EMDQ: Removal of Image Feature Mismatches in Real-Time. IEEE Trans Image Process. 2022;31:706-720. PMID: 34914589; PMC8777235.