The Megrez navigation system (Symbow Medical, Beijing, China) was installed in the Advanced Multimodality Image Guided Operating (AMIGO) suite of the Harvard Medical School and Brigham and Women’s Hospital. Symbowmed joins the family of navigation systems present in AMIGO which include products from BrainLab, Hologic, Robin Medical, and St. Jude. Megrez is a portable system designed to support interventional therapeutic procedures under image guidance, to realize both real-time interactive and offline navigation. Its unique MRI compatible features enabled integration with the high field 3T MRI scanner in AMIGO. The system was also integrated with the PET/CT scanner with the intention to support interventional guidance under both morphological and functional information. The system is being technically evaluated by BWH scientists, with regards to accuracy, safety and efficiency. Possible clinical applications include brain biopsy, and percutaneous abdominal procedures such as biopsy and cryotherapy. The addition of this equipment may aid in the AMIGO team’s efforts to fully utilize all three rooms of the suite. Although similar equipment is available in the center operating room, it is not MRI compatible. The use of Megrez is expected to increase the types of procedures that can be performed in the MRI procedure room.