The Publication Database hosted by SPL
|
All Publications
Upload
Advanced Search
Gallery View
Download Statistics
Help
Import
Log in
Neuropsychiatric Correlates of White Matter Hyperintensities in Alzheimer's Disease
Institution: |
1Geriatric Psychiatry Research Program, McLean Hospital, Belmont, MA, USA. 2Psychiatry, Harvard Medical School, Boston, MA, USA 3Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. |
Publisher: |
John Wiley & Sons, Inc. |
Publication Date: |
Aug-2010 |
Journal: |
Int J Geriatr Psychiatry |
Volume Number: |
25 |
Issue Number: |
8 |
Pages: |
780-8 |
Citation: |
Int J Geriatr Psychiatry. 2010 Aug;25(8):780-8. |
PubMed ID: |
19946864 |
Keywords: |
Alzheimer's disease, behavioral and psychological symptoms of dementia, white matter hyperintensities, magnetic resonance imaging, Neuropsychiatric Inventory |
Appears in Collections: |
SPL |
Generated Citation: |
Berlow Y.A., Wells III W.M., Ellison J.M., Sung Y.H., Renshaw P.F., Harper D.G. Neuropsychiatric Correlates of White Matter Hyperintensities in Alzheimer's Disease. Int J Geriatr Psychiatry. 2010 Aug;25(8):780-8. PMID: 19946864. |
| Export citation: |
To investigate the association of behavioral and psychological symptoms of dementia (BPSD) in Alzheimer's disease (AD) and magnetic resonance imaging (MRI) measures of brain atrophy and white matter hyperintensities (WMH). METHODS: Thirty-seven patients with probable AD received the Neuropsychiatric Inventory (NPI), the Mini Mental Status Exam (MMSE), and an MRI scan as part of their initial evaluation at the Outpatient Memory Diagnostic Clinic at McLean Hospital. MRI-based volumetric measurements of whole brain atrophy, hippocampal volumes, and WMH were obtained. Analysis of covariance models, using age as a covariate and the presence of specific BPSD as independent variables, were used to test for differences in whole brain volumes, hippocampal volumes and WMH volumes. RESULTS: Increased WMH were associated with symptoms of anxiety, aberrant motor behavior, and night time disturbance, while symptoms of disinhibition were linked to lower WMH volume. No associations were found for whole brain or hippocampal volumes and BPSD. CONCLUSIONS: These findings suggest that white matter changes are associated with the presence of BPSD in AD.