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Williams Syndrome and Memory: A Neuroanatomic and Cognitive Approach

Institution:	1School of Psychology, CIPsi, Neuropsychophysiology Lab, University of Minho, Braga, Portugal, adriana.sampaio@iep.uminho.pt. 2Life and Health Sciences Research Institute, University of Minho, Braga, Portugal 3Department of Neuroradiology, Hospital Geral Santo António, Porto, Portugal 4Psychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women’s Hospital, Harvard Medical School, Boston, USA
Publisher:	Springer
Publication Date:	Jul-2010
Journal:	J Autism Dev Disord
Volume Number:	40
Issue Number:	7
Pages:	870-877
Citation:	J Autism Dev Disord. 2010 Jul;40(7):870-7
PubMed ID:	20101451
Keywords:	Williams Syndrome, Neurodevelopment, Hippocampal formation, Memory performance
Appears in Collections:	PNL
Sponsors:	K05 MH 01110/MH/NIMH NIH HHS/United States
Generated Citation:	Sampaio A., Sousa N., Férnandez M., Vasconcelos C., Shenton M.E., Gonçalves O.F. Williams Syndrome and Memory: A Neuroanatomic and Cognitive Approach. J Autism Dev Disord. 2010 Jul;40(7):870-7 PMID: 20101451.
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Williams Syndrome (WS) is described as displaying a dissociation within memory systems. As the integrity of hippocampal formation (HF) is determinant for memory performance, we examined HF volumes and its association with memory measures in a group of WS and in a typically development group. A significantly reduced intracranial content was found in WS, despite no differences were observed for HF absolute volumes between groups. When volumes were normalized, left HF was increased in WS. Moreover, a lack of the normal right > left HF asymmetry was observed in WS. No positive correlations were found between volumetric and neurocognitive data in WS. In sum, a relative enlargement of HF and atypical patterns of asymmetry suggest abnormal brain development in WS.