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White Matter Pathology Isolates the Hippocampal Formation in Alzheimer's Disease
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Salat D.H., Tuch D.S., van der Kouwe A.J.W., Greve D.N., Pappu V., Lee S.Y., Hevelone N.D., Zaleta A.K., Growdon J.H., Corkin S., Fischl B., Rosas H.D.
Institution: |
MGH/MIT/HMS Athinoula A. Martinos Center for Biomedical Imaging, Charlestown, MA 02129-2060, United States. salat@nmr.mgh.harvard.edu |
Publisher: |
Elsevier Science |
Publication Date: |
Feb-2010 |
Journal: |
Neurobiol Aging |
Volume Number: |
31 |
Issue Number: |
2 |
Pages: |
244-256 |
Citation: |
Neurobiol Aging. 2010 Feb;31(2):244-56. |
PubMed ID: |
18455835 |
PMCID: |
PMC3038572 |
Keywords: |
Alzheimer, Aging, Diffusion Tensor Imaging, Fractional Anisotropy, Diffusivity, MRI, White Matter, Dementia, Hippocampus, Entorhinal, Memory, Axial Diffusivity, Radial Diffusivity, Tractography, Volume, Hyperintensities, T2, Myelin, Axon |
Appears in Collections: |
NA-MIC |
Sponsors: |
AG05886 (AG) funded by NIA NIH HHS K01 AG024898 (AG) funded by NIA NIH HHS P41 RR14075 (RR) funded by NCRR NIH HHS U54 EB005149 (EB) funded by NIBIB NIH HHS |
Generated Citation: |
Salat D.H., Tuch D.S., van der Kouwe A.J.W., Greve D.N., Pappu V., Lee S.Y., Hevelone N.D., Zaleta A.K., Growdon J.H., Corkin S., Fischl B., Rosas H.D. White Matter Pathology Isolates the Hippocampal Formation in Alzheimer's Disease. Neurobiol Aging. 2010 Feb;31(2):244-56. PMID: 18455835. PMCID: PMC3038572. |
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Prior work has demonstrated that the memory dysfunction of Alzheimer's disease (AD) is accompanied by marked cortical pathology in medial temporal lobe (MTL) gray matter. In contrast, changes in white matter (WM) of pathways associated with the MTL have rarely been studied. We used diffusion tensor imaging (DTI) to examine regional patterns of WM tissue changes in individuals with AD. Alterations of diffusion properties with AD were found in several regions including parahippocampal WM, and in regions with direct and secondary connections to the MTL. A portion of the changes measured, including effects in the parahippocampal WM, were independent of gray matter degeneration as measured by hippocampal volume. Examination of regional changes in unique diffusion parameters including anisotropy and axial and radial diffusivity demonstrated distinct zones of alterations, potentially stemming from differences in underlying pathology, with a potential myelin specific pathology in the parahippocampal WM. These results demonstrate that deterioration of neocortical connections to the hippocampal formation results in part from the degeneration of critical MTL and associated fiber pathways.
Additional Material
1 File (258.361kB)
Salat-NeurobiologyofAging2010-fig2.jpg (258.361kB)