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Toward 13C Hyperpolarized Biomarkers Produced by Thermal Mixing with Hyperpolarized 129Xe
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Institution: |
Enhanced Magnetic Resonance Laboratory, Huntington Medical Research Institutes, Pasadena, California 91105, USA. nlisitza@partners.org |
Publisher: |
J Chem Phys |
Publication Date: |
Jul-2009 |
Volume Number: |
131 |
Issue Number: |
4 |
Citation: |
J Chem Phys. 2009 Jul 28;131(4):044508. |
PubMed ID: |
19655895 |
PMCID: |
PMC2730707 |
Appears in Collections: |
CPFI |
Sponsors: |
1K99CA134749-01 (CA) funded by NCI NIH HHS R01CA122513 (CA) funded by NCI NIH HHS R01HL073632 (HL) funded by NHLBI NIH HHS |
Generated Citation: |
Lisitza N., Muradian I., Frederick E., Patz S., Hatabu H., Chekmenev E.Y. Toward 13C Hyperpolarized Biomarkers Produced by Thermal Mixing with Hyperpolarized 129Xe. J Chem Phys. 2009 Jul 28;131(4):044508. PMID: 19655895. PMCID: PMC2730707. |
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The 13C NMR signal of acetic acid 1-13C-AcH is enhanced by polarization transfer from hyperpolarized 129Xe using a thermal mixing procedure. 1-13C-AcH acid and hyperpolarized 129Xe are mixed as gases to disperse 129Xe in the acetic acid. The mixture is frozen with liquid N(2) at 0.5 T. The magnetic field is then momentarily dropped to allow for exchange of spin polarization between 13C and 129Xe. After polarization exchange the magnetic field is raised to its original value and the mixture is thawed, resulting in a solution of polarization enhanced 1-13C-AcH. A 13C nuclear spin polarization enhancement of 10 is observed compared to its thermal polarization at 4.7 T. This polarization enhancement is approximately three orders of magnitude lower than that predicted by theory. The discrepancy is attributed to the formation of either an inhomogeneous solid matrix and/or spin dynamics during polarization transfer. Despite the low polarization enhancement, this is the first report of polarization transfer from 129Xe to 13C nuclear spins achieved by thermal mixing for a proton-containing molecule of biomedical importance. If future work can increase the enhancement, this method will be useful in hyperpolarizing a wide range of 13C enriched compounds important in biomedical and biophysical research.
Additional Material
1 File (230.699kB)
Lisitza-JChemPhys2009-fig2.jpg (230.699kB)