Shear-Mode Transcranial Ultrasound Imaging R21-EB004353
In this internal collaboration between the Imaging and Focused Ultrasound Cores of the NCIGT, researchers are improving transcranial ultrasound by propagating sound waves through the skull as a shear wave as opposed to a longitudinal acoustic mode. The investigation is testing the application of the transcranial shear mode to a number of imaging problems including vessel detection, tumor detection, tissue morphology, and brain hemorrhaging. The work could culminate in a non-ionizing clinically-applied imaging method.
Since its inception, the collaboration's investigators have completed a study on a single channel device for shear-mode transcranial ultrasound that was tested in a clinical study at Boston University Medical Center, a study on random-frequency imaging method that would make it possible to perform 2D imaging at the low frequencies necessary to image throughout the skull, a study on the properties of fresh bone tissues vs. reconstituted bone tissue, a preliminary study of a new transducer and imaging method for imaging in 2D with a single transducer at low frequencies necessary to image through the skull, and a study that characterizes, for the first time, the shear-mode acoustic properties of the skull bone.
Publications
- White PJ, Clement GT. Two-dimensional localization with a single diffuse ultrasound field excitation. IEEE Trans Ultrason Ferroelectr Freq Control. 2007 Nov;54(11):2309-17. PMID: 18051165.
- Tang SC, Clement GT, Hynynen K. A computer-controlled ultrasound pulser-receiver system for transskull fluid detection using a shear wave transmission technique. IEEE Trans Ultrason Ferroelectr Freq Control. 2007 Sep;54(9):1772-83. PMID: 17941383.
- White PJ, Palchaudhuri S, Hynynen K, Clement GT. The effects of desiccation on skull bone sound speed in porcine models. IEEE Trans Ultrason Ferroelectr Freq Control. 2007 Aug;54(8):1708-10.PMID: 17703676.
- Clement GT. Two-dimensional ultrasound detection with unfocused frequency-randomized signals. J Acoust Soc Am. 2007 Jan;121(1):636-47. PMID ID: 17297817.