MR Guided Focused Ultrasound Surgery for Prostate Cancer R01-CA109246
The Prostate and Focused Ultrasound Cores are developing an integrated multimodal image display system to allow accurate targeting of focal prostate lesions for MR-guided focused ultrasound surgery (MRgFUS). For this system, rapid and spatially accurate thermal imaging will be required, not only at the focal point, but at the critical normal, adjacent structures, such as the urethra and neurovascular bundles. In 2008, investigators began the preclinical tests in dogs of a transrectal MRgFUS system for the thermal ablation of prostate cancer. The system being evaluated is the ExAblate 2000 Prostate made by InSightec, Inc. Animal tests demonstrate how MRI-guidance can offer controlled and precise ablation of prostatic volumes. MRI-guidance allows controlled thermal dosimetry deposition to provide precise targeting and adequate exposure levels. Current challenges include tracking prostate motion and reducing motion-induced artifacts in the MRI.
In 2009, researchers completed canine prostate MRgFUS experiments using a prototype prostate MRgFUS device from Insightec.
Publications
- Roebuck J, Haker S, Mitsouras D, Rybicki F, Tempany C, Mulkern R. Carr-Purcell-Meiboom-Gill imaging of prostate cancer: quantitative T2 values for cancer discrimination. Magn Reson Imaging. 2009 May;27(4):497-502. PMID: 18823731.
- McDannold N, Tempany C, Jolesz F, Hynynen K. Evaluation of referenceless thermometry in MRI-guided focused ultrasound surgery of uterine fibroids. J Magn Reson Imaging. 2008 Oct;28(4):1026-32. PMID: 18821603. PMCID: PMC2574694.
- Hata N, Tokuda J, Hurwitz S, Morikawa S. MRI-compatible manipulator with remote-center-of motion control. J Magn Reson Imaging. 2008 Apr 11;27(5):1130-1138. PMID: 18407542.
- Tempany CMC, Straus S, Hata N, Haker S. MR-guided prostate interventions. J Magn Reson Imaging, 2008 Feb;27(2):356-67. PMID: 18219689.
- Fan A, Fisher III JW, Wells III W, Levitt JJ, Willsky AS.MCMC Curve Sampling for Image Segmentation. Int Conf Med Image Comput Comput Assist Interv. 2007;10(Pt 2):477-485. PMID: 18044603.
- Hata N, Piper S, Jolesz FA, Tempany CM, Black PM, Morikawa S, Iseki H, Hashizume M, Kikinis R. Application of open source image guided therapy software in MR-guided therapies. Int Conf Med Image Comput Comput Assist Interv. 2007;10(Pt 1):491-8. PMID: 18051095.
- Roebuck JR, Mitsouras D, Haker SJ, Rybicki FJ, Tempany CM, Mulkern RV. Carr-Purcell-Meiboom-Gill (CPMG) imaging of prostate cancer; Trading time for information: High quality T2 images and quantitative T2 for cancer discrimination. Abstract, ISMRM 2007.
- Wong PY, Szot Barnes A, Haker S, Zou KH, D’Amico AV, Tempany CM, Hata N. Displacement of neurovascular bundles before and after MRI-guided prostate brachytherapy. Abstract, ISMRM 2007.
- Nain D, Haker S, Bobick A, Tannenbaum A. Multiscale 3D shape representation and segmentation using spherical wavelets. IEEE Trans Med Imaging. 2007 Apr;26(4):598-618. PMID: 17427745.
- Nain D, Haker S, Bobick A, Tannenbaum A. Shape-Driven 3D Segmentation Using Spherical Wavelets. Int Conf Med Image Comput Comput Assist Interv. 2006;9(Pt 1):66-74. PMID: 17354875.
- Mulkern RV, Barnes AS, Haker SJ, Hung YP, Rybicki FJ, Maier SE, Tempany CMC. Biexponential characterization of prostate tissue water diffusion decay curves over an extended b-factor range. Magn Reson Imaging. 2006 Jun;24(5):563-8. PMID: 16735177.
- Yang Y, Zhu L, Haker S, Tannenbaum AR, Giddens DP. Harmonic skeleton guided evaluation of stenoses in human coronary arteries. Int Conf Med Image Comput Comput Assist Interv. 2005;8(Pt 1):490-7. PMID: 16685882.
- Nain D, Haker S, Bobick A, Tannenbaum A. Multiscale 3D shape analysis using spherical wavelets. Int Conf Med Image Comput Comput Assist Interv. 2005;8(Pt 2):459-67. PMID: 16685992.
- Zhu L, Haker S, Tannenbaum A. Mass Preserving Registration for Heart MR Images. Int Conf Med Image Comput Comput Assist Interv. 2005;8(Pt 2):147-54. PMID: 16685954.